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Tuesday, January 31, 2012
Manage your Sprint account on your iPhone with Sprint Mobile Zone for
Sprint has released an iPhone app for their customers called Sprint Mobile Zone. With this app, users can access their Sprint accounts, check out promotions, and read Sprint news. Non-account
Monday, January 30, 2012
Greece should give up budget control: Germany (Reuters)
BERLIN (Reuters) ? Greece must surrender control of its budget policy to outside institutions if it cannot implement reforms attached to euro zone rescue measures, the German economy minister was quoted as saying on Sunday.
Philipp Roesler became the first German cabinet member to openly endorse a proposal for Greece to surrender budget control after Reuters quoted a European source on Friday as saying Berlin wants Athens to give up budget control.
"We need more leadership and monitoring when it comes to implementing the reform course," Roesler, also vice chancellor, told Bild newspaper, according to an advance of an interview to be published on Monday.
"If the Greeks aren't able to succeed themselves with this, then there must be stronger leadership and monitoring from abroad, for example through the EU," added Roesler, chairman of the Free Democrats (FDP) who share power with Chancellor Angela Merkel.
Reuters reported on Friday that Germany wants Greece to give up control of budget policy to European institutions as part of discussions over a second rescue package.
Greece, which has repeatedly failed to meet the fiscal targets set out by its international lenders, is in talks to finalise a second 130 billion-euro ($172 billion) package.
With many Greeks blaming Germans for the austerity medicine their country has been forced to swallow, officials in Athens dismissed the idea of relinquishing budget control as out of the question.
Finance Minister Evangelos Venizelos said on Sunday Greece was perfectly capable of making good on its promises.
"Anyone who puts a nation before the dilemma of 'economic assistance or national dignity' ignores some key historical lessons," he said in a statement before heading to Brussels for a European Union summit on Monday.
The Financial Times reported on Saturday that it had obtained a copy of the proposal showing Germany wants a new euro zone "budget commissioner" to have the power to veto budget decisions taken by the Greek government if they are not in line with targets set by international lenders.
"Given the disappointing compliance so far, Greece has to accept shifting budgetary sovereignty to the European level for a certain period of time," the document said.
Under the plan, Athens would only be allowed to carry out normal state spending after servicing its debt, the paper said.
Crushed by 350 billion euros ($462 billion) of debt and running out of cash quickly, Greece is scrambling to appease the "troika" of its official lenders - the European Commission, European Central Bank and International Monetary Fund - and stitch up a deal with private creditors simultaneously.
Greece needs to strike a deal with creditors in the next couple of days to unlock its next aid package in order to avoid a chaotic default.
A government source in Berlin said Germany's proposal was aimed not just at Greece but also at other struggling euro zone members that receive aid and are unable to make good on their obligations.
The European Commission, the executive arm of the 27-country bloc, said it wanted the Greek government to maintain autonomy.
(Editing by Alessandra Rizzo)
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Mobile Miscellany: week of January 23, 2012
This week may not have been incredibly packed with news in the mobile world, but it was still easy to miss a few stories here and there. Here's some of the other stuff that happened in the wide world of wireless for the week of January 23, 2012:
Continue reading Mobile Miscellany: week of January 23, 2012
Mobile Miscellany: week of January 23, 2012 originally appeared on Engadget on Sat, 28 Jan 2012 17:34:00 EDT. Please see our terms for use of feeds.
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Sunday, January 29, 2012
Yemeni president heads to US for medical treatment (AP)
SANAA, Yemen ? Yemeni President Ali Abdullah Saleh headed to the United States on Saturday for medical treatment, his spokesman said, the latest stage in an effort to distance him from his country's policies to help ease a transition from his rule.
Ahmed al-Soufi, the press officer for the presidency, told The Associated Press that Saleh had arrived in London and would leave later Saturday for New York for medical treatment in the United States for wounds suffered in a June assassination attempt in the Yemeni capital.
Saleh left Yemen for to neighboring Oman a week ago, planning to head to the United States, after weeks of talks with the U.S. over where he could go. Washington has been trying to get Saleh to leave his homeland, but it does not want him to settle permanently in the United States, fearing it would be seen as harboring a leader considered by his people to have blood on his hands.
In London, a Foreign Office spokeswoman confirmed that Saleh's plane was scheduled to land Saturday at a British commercial airport "to refuel en route to the United States." Speaking on condition of anonymity in line with government policy, she said Saleh and those accompanying him were not going to enter the United Kingdom.
Saleh was traveled on a chartered Emirates plane with a private doctor, translator, eight armed guards and several family members, an official in the Yemeni president's office said, speaking on condition of anonymity because he was not authorized to release the details.
In November, Saleh handed over his powers to his vice president and promised to step down completely after months of protests by millions across the country demanding an end to his nearly 33-year rule. A national unity government was formed between his ruling party and the opposition.
But opponents say he has continued to interfere in the work of a unity government through his allies and relatives in key posts ? particularly his son and nephew, who command the country's most elite and powerful military units. As a result, the past two months have seen persistent violence, power struggles and delays in reforms.
The U.S. and its allies have been pressured Saleh to leave in hopes of removing him from the scene will smoothen the transition.
Saleh agreed to step down in return for a sweeping immunity from prosecution on any crimes committed during his rule, a measure that has angered many in Yemen who want him tried for the deaths of protesters in his crackdown on the uprising against him. Protests have continued demanding his prosecution and the removal of his relatives and allies from authority.
It is also unclear how permanent Saleh's exile is. In a farewell speech before leaving to Oman, Saleh promised to return to Yemen before Feb. 21 presidential elections as the head of his party.
Some in Yemen suspect Saleh is still trying to slip out of the deal and find ways to stay in power, even if it's behind the scenes.
Even since the protests against his rule began a year ago, Saleh has proved a master in eluding pressure to keep his grip, though over the months his options steadily closed around him. He slipped out of signing the accord for the power handover three times over the months before finally agreeing to it.
He was badly burned in a June explosion in his compound in Sanaa. He received medical treatment in neighboring Saudi Arabia for three months. American officials had hoped he would remain there, but the Yemeni leader returned home and violence worsened anew.
His maneuvering and the turmoil on the ground left the United States struggling to find a stable transition in the country to ensure a continued fight against al-Qaida militants based in the country, who make up the most active branch of the terror network in the world. Saleh was a close ally of Washington in the fight, taking millions in counterterrorism aid.
During the past year of turmoil, al-Qaida-linked militants outright took control of several cities and towns in the south, including Zinjibar, the capital of Abyan province.
On Friday, government forces battled with the militants near the town of Jaar, which they also control. At least five people were killed in the fighting, Yemeni security officials said Saturday, speaking on condition of anonymity because they were not authorized to talk to the press.
___
AP correspondent Jill Lawless in London contributed to this report.
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[OOC] A Candle in the Darkness
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Saturday, January 28, 2012
Manning, Irsay insist they are on same page (AP)
INDIANAPOLIS ? Peyton Manning and Colts owner Jim Irsay insist they are just fine after a week filled with complaints and comments suggesting a rift had developed following one of the most miserable seasons in team history.
"We would like to dispel any misperception that there might be any hard feelings between us," the two said Friday in a statement issued by the team. "Since 1998, we have enjoyed a great relationship, based upon mutual respect and trust. We have always been able to talk and address matters we've faced over the years, not just as owner and player, but as friends.
"We had a long talk today and we want to assure Colts fans everywhere that we are both committed to maintaining our close relationship and to working together through any challenges the future may bring."
That would be welcome news to Colts fans, who first watched Manning publicly complain about the down-in-the-mouth atmosphere at team headquarters and then two days later saw Irsay call out his franchise quarterback at a news conference intended to focus on the new head coach.
It's been a dizzying week.
On Tuesday, Manning told The Indianapolis Star that his only real conversation so far with the new general manager Ryan Grigson had come in passing and the flurry of firings had those around the team complex walking on "eggshells."
Irsay didn't like that Manning went public with his frustrations and he said so Thursday, calling Manning a "politician."
"I don't think it's in the best interest to paint the horseshoe in a negative light, I really don't," Irsay told reporters following Chuck Pagano's introduction as coach. "The horseshoe always comes first, and I think one thing he's always known, because he's been around it so long, is that, you know, you keep it in the family. If you've got a problem you talk to each other, it's not about campaigning or anything like that."
Apparently, Manning got the message.
Just a few hours later, Manning told the newspaper that he didn't intend to create a public spat. Instead, Manning said he was speaking from the heart after watching so many of his friends lose their jobs.
"At this point, Mr. Irsay and I owe it to each other and to the fans of the organization to handle this appropriately and professionally, and I think we will. I've already reached out to Mr. Irsay," Manning said. "I wasn't trying to paint the Colts in a bad light, but it's tough when so many people you've known for so long are suddenly leaving. I feel very close to a lot of these guys and we've done great things together. It's hard to watch an old friend clean out his office. That's all I was trying to say."
And Irsay tweeted after that: "Peyton and I love each other,that goes without saying..I humbly serve n protect the Horseshoe..it is bigger than any individual,including me."
Whether the two have mended their misunderstanding, there are still huge questions pending. Irsay must decide by March 8 whether to pay Manning a $28 million bonus. Manning missed the entire 2011 season after having his third neck surgery in September.
Irsay just this month has fired vice chairman Bill Polian, general manager Chris Polian, coach Jim Caldwell and most of the staff. Pagano, the Baltimore Ravens' defensive coordinator this past season, is just getting started, as is Grigson.
Indy's poor season has given it the No. 1 overall pick, which Irsay has said they will use for their quarterback of the future, presumably Stanford's Andrew Luck. If so, Irsay must decide if he wants to pay a No. 1 quarterback and Manning, who signed a five-year, $90 million contract in July and will be 36 in late March.
Irsay has said his choice will come down to Manning's health, not money.
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Friday, January 27, 2012
This is getting nasty now
Getty ImagesBills QB Ryan Fitzpatrick suggested the team wasn?t ready to handle success this season.
G.M. Jeff Ireland hopes to uncover some future Dolphins at the Senior Bowl.
Patriots S James Ihedigbo showed Giants WR Victor Cruz around the UMass campus seven years ago.
A strong review of the upcoming HBO documentary about former Jets QB Joe Namath.
Kevin Cowherd of the Baltimore Sun comes up with some reasons why the Ravens should keep offensive coordinator Cam Cameron.
With no more head coaching vacancies, Mike Zimmer is back to solely concentrating on the Bengals defense.
Members of the Browns hierarchy won?t be in Indianapolis for the Super Bowl.
An appreciation of the career of DL Chris Hoke, who is retiring from the Steelers.
New coaches and new players made a big difference in the Texans secondary.
Said Colts coach Chuck Pagano about whether he?ll coach QB Peyton Manning, ?Uh, you know, I?ve got a text or call out to Rob Lowe and I haven?t heard back from Rob yet. I?m going to have to get back to you on that one.?
The Jaguars haven?t gotten much from their recent top draft picks.
A look at the Titans through the financial lens.
The Broncos could use a bit more pass rush from the middle of the line.
Figuring out how much to use Dexter McCluster is something the Chiefs need to do this offseason.
Said Raiders P Shane Lechler of new coach Dennis Allen, I think it will be a good fit for us. ?He?s a young, energetic guy. Smart guy. Been through a lot with Atlanta, then a lot with New Orleans, over to Denver and that defense. We?ll take all the help we can get right now.?
Chargers QB Philip Rivers doesn?t think the team is a long way from a return to the playoffs.
Cowboys RB DeMarco Murray says that he doesn?t pay attention to negative tweets.
Indianapolis will be a trip to the Super Bowl and a trip home for Giants LB Mathias Kiwanuka.
Eagles coach Andy Reid finally sat down and shared his thoughts about ? basketball.
New Redskins receivers coach Ike Hilliard is still getting the team?s offensive terminology down.
The new Bears general manager will have to hit the ground running.
North Alabama CB Janoris Jenkins is a player that Lions fans should keep an eye on in the Senior Bowl.
Packers C Scott Wells is enjoying the Pro Bowl before he starts worrying about his future.
New Vikings defensive coordinator Alan Williams said the team?s players have a clean slate this offseason.
Who are the likeliest cap casualties with the Falcons?
Panthers QB Cam Newton was catching some passes from Aaron Rodgers at Pro Bowl practice.
Said Saints T Jermon Bushrod, ?Teams fall short. It?s gonna happen every year. And it definitely still stings a little. But you?ve got to stick together as a team and remember there?s always next year. ? We?re too blessed to be down for too long.?
Buccaneers G Jeremy Zuttah played for Greg Schiano at Rutgers and looks forward to playing for him again in Tampa.
The Cardinals? coaching staff might be impacted by Greg Schiano?s arrival in Tampa.
Bryan Burwell of the St. Louis Post-Dispatch wonders what keeping the Rams is really worth to St. Louis.
Wide receivers will be the first priority for the 49ers this offseason.
Seahawks S Earl Thomas is enjoying his first trip to the Pro Bowl.
Source: http://profootballtalk.nbcsports.com/2012/01/26/irsay-calls-peyton-manning-a-politician/related/
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Google adding Public Alerts to Maps, keeps you in the loop in times of worry
You can't deny that Google often hands out marvelous tools for the masses to utilize (yes, some can be a miss), and today the King of Search is launching a fresh virtual apparatus as part of its Crisis Response project. Dubbed "Public Alerts," the feature is accessible from within Google Maps, keeping you in the loop during times of high alert. Your search query will trigger things like weather relevant to your area, public safety and earthquake alerts -- all of which are provided by the NOAA, the National Weather Service and the US Geological Survey. The Crisis Response squad says its goal is "to surface emergency information through the online tools you use everyday," which is a great idea, but we honestly hope that you don't have to use it very often. Those of you stateside can start using Public Alerts now -- as for the rest, let's hope that the search giant brings its alerts to a map near you sooner rather than later...
Google adding Public Alerts to Maps, keeps you in the loop in times of worry originally appeared on Engadget on Wed, 25 Jan 2012 16:37:00 EDT. Please see our terms for use of feeds.
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Thursday, January 26, 2012
Video: Under the electron microscope - a 3-D image of an individual protein
Wednesday, January 25, 2012
When Gang Ren whirls the controls of his cryo-electron microscope, he compares it to fine-tuning the gearshift and brakes of a racing bicycle. But this machine at the U.S. Department of Energy (DOE)'s Lawrence Berkeley National Laboratory (Berkeley Lab) is a bit more complex. It costs nearly $1.5 million, operates at the frigid temperature of liquid nitrogen, and it is allowing scientists to see what no one has seen before.
At the Molecular Foundry, Berkeley Lab's acclaimed nanotechnology research center, Ren has pushed his Zeiss Libra 120 Cryo-Tem microscope to resolutions never envisioned by its German manufacturers, producing detailed snapshots of individual molecules. Today, he and his colleague Lei Zhang are reporting the first 3-D images of an individual protein ever obtained with enough clarity to determine its structure.
Scientists routinely create models of proteins using X-ray diffraction, nuclear magnetic resonance, and conventional cryo-electron microscope (cryoEM) imaging. But these models require computer "averaging" of data from analysis of thousands, or even millions of like molecules, because it is so difficult to resolve the features of a single particle. Ren and Zhang have done just that, generating detailed models using electron microscopic images of a single protein.
He calls his technique "individual-particle electron tomography," or IPET. The work is described in the January 24 issue of PLoS One, the open-source scientific journal, in an article entitled "IPET and FETR: Experimental Approach for Studying Molecular Structure Dynamics by Cryo-Electron Tomography of a Single-Molecule Structure."
The 3-D images reported in the paper include those of a single IgG antibody and apolipoprotein A-1 (ApoA-1), a protein involved in human metabolism. Ren's goal is to produce individual 3-D images of medically significant proteins, such as HDL? the heart-protective "good cholesterol" whose structure has eluded the efforts of legions of scientists armed with far more powerful protein modeling tools. "We are well on our way," says Ren.
Ren has the credentials of one who knows what he can do. He was recruited to work at Berkeley Lab in August 2010 from the University of California at San Francisco, where he had used a cryo-electron microscope and more conventional averaging techniques to discern the 3-D structure of LDL ? the "bad cholesterol" thought to be a major risk factor for heart disease.
His images of single proteins are a bit fuzzy, even after they are cleaned up by complex computer filtering, but very informative to the trained observer. These individual particles are extraordinarily tiny, requiring Ren to zero in on a spot of less than 20 nanometers. He has reported protein images as small as 70 kDa. That's kilodaltons, a Lilliputian scale (expressed in units of mass) set aside for taking the measure of atoms, molecules, and snippets of DNA. It's a more useful way to size soft objects like proteins that can be clumped, stringy, or floppy.
Unlike the sculptural images of protein models, a suite of these photographs can convey a sense of these particles in all their nanoscale floppiness. Within the complex structure of these proteins lies the secrets of their function, and perhaps keys to drugs that block the bad ones and promote the good ones. With some additional computer filtering, a high-contrast model of protein can be generated from the images and animated to show its moving parts in 3-D.
"This allows you to see the personality of each protein,'' says Ren. "It is a proof of concept for something that people thought was impossible."
A computer animation demonstrates the flexible dynamics ? the moving parts ? of human IgG antibody. 3-D images of two individual antibody particles (gray) were generated using EM tomography with IPET. The demonstration shows how the same molecular chains (red, orange, and green noodle-like models) of antibody particle #1 can fit precisely into particle #2, which was found under the microscope in an entirely different pose.
How did Ren coax so much versatility out of his Libra 120? "It's not a very high-end model,'' he concedes. Much has to do with the accessories he bolts on to the machine, and with his own artistry and patience. He's equipped the microscope with a $300,000 CCD camera, some powerful image-processing software, special contrasting agents, and a device called an "energy filter" that sifts through the digitized camera data and culls weak signals. Thoroughly familiar with his customized machine, he also employs an element of elbow grease, working long hours to draw out the powerful images from a torrent of digital noise.
The multiple angles used to create the 3-D portrait help resolve the faint molecular image. "All images are noisy," Ren explains. "In physics, the noise is inconsistent among the images, but the signal ? the object or protein ? is consistent. By using this approach, we find the consistent portion (the signal) can be enhanced, while the inconsistent portion (the noise) will be reduced substantially."
Electron microscopes focus streams of electrons rather than light to see incredibly tiny things. The short wavelength of an electron beam enables much higher resolution and magnification than visible light. Powerful electron microscopes have been used for decades to probe materials at atomic-scale; and right next door to the Molecular Foundry is Berkeley Lab's National Center for Electron Microscopy, which houses the most powerful microscopes in the world. The TEAM 0.5 microscope can distinguish objects as small as the radius of a hydrogen atom. But these heavyweight microscopes pull off this atomic-scale resolution with pulses of energy that would obliterate most soft biological proteins. The high power electron microscopes are used primarily for probing atomic structure of strong, solid materials, such as graphene ? a lattice of carbon only one atom thick.
Ren's lab specializes in cryoEM, which examines objects frozen at -180 ?C (-292 ?F). A bath of liquid nitrogen flash-freezes samples so quickly that no ice crystals form. "It is amorphous, like glass,'' Ren says. The protein samples are frozen on a disk the size of baby's fingernail, filled with tiny wells 2 microns across. The disk is inserted into the microscope on a rotating support that can tilt the sample up to 140? inside a vacuum ? sufficient camera angles to produce a 3-D perspective. "The challenge is to isolate it from the air, and to turn it without vibrations, even the vibrations from the bubbling of liquid nitrogen,'' says Ren.
The extremely low temperature fixes the samples and prevents them from drying out in the vacuum needed for the electron scan. It creates conditions favorable for imaging at much lower doses of electrons ? low enough to keep a single soft protein intact while more than 100 images are taken over a one-to-two hour period.
###
DOE/Lawrence Berkeley National Laboratory: http://www.lbl.gov
Thanks to DOE/Lawrence Berkeley National Laboratory for this article.
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Take Better Notes, Draw Your Thoughts, and Rock Out With Your Finger [App Deals Of The Day]
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Wednesday, January 25, 2012
PFT: Big Ben case settled for small amount?
Earlier today, we suggested that folks thinking about buying an NFL jersey should consider waiting until April of this year, when the switch flips from Reebok to Nike.? But with a Nike exec saying in October 2010 that the company plans on ?changing the NFL jersey dramatically,? the league is now saying otherwise.
?Logos are controlled by teams and the NFL,? league spokesman Brian McCarthy told PFT by email this morning.? ?That will not change.? Teams have to apply to league to make changes to logos and colors.
?We anticipate new uniform technology (i.e., performance-driven, lighter materials).? That?s what Nike?s [Charlie] Denson was referring to in his interview in 2010 regarding changes.?
So, apparently, the jerseys will look the same, barring any changes that would be made in the ordinary course of changing jerseys.? Of course, the shift to Nike could cause some teams to decide to make the change.
Last year, for example, Seahawks president Peter McLoughlin said that the team will use the occasion to re-do their duds.? ?There will be no changes for ?11, for the upcoming season,? McLoughlin told Dave ?Softy? Mahler of KJR.? ?2011 is the final year for the Reebok deal with the NFL, and starting in 2012 we?re going to be going with a Nike jersey and a Nike design.? So we?ve actually met with Nike, and I think we were the first NFL team to meet with them, and we had a fascinating session with them.? Pete Carroll was in the room, John Schneider, all kinds of people, and we?re looking at all kinds of new designs, and new kinds of jerseys, and we?re talking about a throwback for sure.? So there?s a lot of creative stuff in the works right now.?
Thus, we won?t know for sure the team jerseys that will look different until the new jerseys are unveiled.? The league says that?ll happen in late April, in connection with the 2012 draft.
As to players changing jersey numbers, McCarthy said that the policy won?t change.? Players wanting to change their numbers will have to submit requests to the team, and the team will then pass the requests along to the league.? Still, NFL spokesman Greg Aiello separately tells PFT that the requirement that a player who changes his number refund Reebok for the unsold inventory of jerseys bearing the prior number will go away in conjunction with the changeover.
So if, for example, Adrian Peterson wants to change his number (as he said he wants to do on his Twitter page), he won?t have to write a check to Reebok.
The bigger takeaway is that Nike won?t be unleashing haphazardly a new array of alternative looks and designs.
We think.
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Tuesday, January 24, 2012
Women on the Pill have less menstrual pain (Reuters)
NEW YORK (Reuters Health) ? Young women on birth control pills tend to have less painful menstrual periods than those not on the contraceptives, a new study finds.
Swedish researchers found that of 2,100 women followed from age 19 to 24, those on the combined birth control pill (estrogen and progestin) had less-severe menstrual pain over time.
It's already common practice for doctors to recommend the Pill to women with dysmenorrhea -- menstrual cramps, back pain and other symptoms that are severe enough to disrupt a woman's life.
Birth control pills are not specifically approved for that purpose, but doctors can prescribe them for dysmenorrhea on an "off-label" basis. However, it has not been clear how effective the pills are against period pain.
The new findings are not conclusive, but still caused excitement among some researchers.
"Our study provides evidence for the effective relief of painful periods with combined oral contraceptives," said Dr. Ingela Lindh of Gothenburg University in Sweden, who led the study.
Both Lindh and one of her co-researchers have financial ties to companies that make hormonal contraceptives, although the new research was not supported by drugmakers.
Menstrual pains typically fade as a woman gets older, and they often lessen after childbirth. But even when age and childbirth were taken into account, Pill users had less painful periods in the new study, Lindh told Reuters Health in an email.
The study, published in the journal Human Reproduction, does not prove that the Pill eases dysmenorrhea.
It's an observational study that looked at the relationship between women's Pill use and dysmenorrhea risk. Clinical trials -- where people are randomly assigned to take a drug or a placebo -- are considered the "gold standard" for proving cause-and-effect.
And a 2009 review of 10 clinical trials concluded that there was "limited evidence" that the Pill improved menstrual pain.
Still, the trials in that review varied in their methods and their quality, so it's hard to draw firm conclusions, according to Dr. Michele Curtis of the University of Texas Medical School at Houston, who was not involved in the current study.
She told Reuters Health the new study isn't definite, but "makes a strong case" that the Pill is effective against menstrual pain.
"I think combined oral contraceptives really do help women with primary dysmenorrhea," said Curtis, who has received speaking fees from drugmaker GlaxoSmithKline, according to ProPublica's database Dollars for Docs.
Primary dysmenorrhea refers to menstrual pain that is not caused by underlying medical conditions such as endometriosis, a disorder of the uterine lining, or non-cancerous uterine growths called fibroids. When a medical condition is the cause, it's known as secondary dysmenorrhea.
A weakness of the current study, Curtis said, is that it did not determine whether women had primary or secondary dysmenorrhea. In some cases of secondary dysmenorrhea, she said, birth control pills might help, but in other cases will do nothing.
The study included three groups of young women who were 19 years old in either 1981, 1991 or 2001. They all completed a standard questionnaire on menstrual symptoms, then repeated the survey five years later.
Dysmenorrhea was common, the study found. Of the 1981 group, 37 percent had at least moderate menstrual pain that disrupted their daily activities; in the 2001 group, that figure was 47 percent.
But Pill users had less pain over the next five years. Overall, Pill use was linked to a reduction of 0.3 units on the pain scale. That means every third woman on the Pill went "one step down" on the scale -- from severe pain to moderate pain, for example -- according to Lindh.
The researchers also looked at subgroups of women who were using the Pill at the age of 19, but not at age 24. On average, their menstrual pain increased over time. In contrast, pain decreased among women who were not on the Pill at age 19, but were at age 24.
There are biological reasons that the Pill would help with dysmenorrhea, both Lindh and Curtis said.
Menstruation causes increased muscle activity in the uterus, which lessens blood flow to the uterus. And that's believed to be the root of menstrual pain.
Hormone-like compounds called prostaglandins help churn up that extra muscle activity. Since birth control pills lower the body's prostaglandin production, Lindh explained, it makes sense that they would ease dysmenorrhea.
Birth control pills, which cost anywhere from $15 to $50 a month, are not the only treatment for dysmenorrhea.
Some women can find enough relief from nonsteroidal anti-inflammatory drugs (NSAIDs), like ibuprofen and naproxen, according to Curtis. NSAIDs also block prostaglandin production.
What's more, vitamin B1 and magnesium, exercise, relaxation techniques and acupuncture have all been advocated for dysmenorrhea.
"Clearly, our evidence base is smaller for those things," Curtis said. But she also said that if a woman does not want birth control or NSAIDs, she could try an alternative.
Birth control pills can have side effects like breast tenderness, nausea and vomiting, and spotting between periods. Pill users also have a slightly higher-than-average risk of blood clots, particularly if they smoke or are age 35 or older.
But most women with primary dysmenorrhea are younger. In fact, Curtis said, if you start having painful periods for the first time when you are 30, it's unlikely that it's primary dysmenorrhea. A secondary cause is probably at work.
The new study was funded by grants from the Gothenburg Medical Society and other groups.
SOURCE: http://bit.ly/zTpZa5 Human Reproduction, online January 17, 2012.
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Plant flavonoid luteolin blocks cell signaling pathways in colon cancer cells
ScienceDaily (Jan. 22, 2012) ? Luteolin is a flavonoid commonly found in fruit and vegetables. This compound has been shown in laboratory conditions to have anti-inflammatory, anti-oxidant and anti-cancer properties but results from epidemiological studies have been less certain. New research published in BioMed Central's open access journal BMC Gastroenterology shows that luteolin is able to inhibit the activity of cell signaling pathways (IGF and PI3K) important for the growth of cancer in colon cancer cells.
Colon cancer is the second most frequent cause of cancer-related death in the Western World. Colon cancer cells have elevated levels of IGF-II compared to normal colon tissues. It is thought that this is part of the mechanism driving uncontrolled cell division and cancer growth. Researchers from Korea showed that luteolin was able to block the secretion of IGF-II by colon cancer cells and within two hours decreased the amount of receptor (IGF-IR) precursor protein. Luteolin also reduced the amount of active receptor (measured by IGF-I dependent phosphorylation).
Luteolin inhibited the growth stimulatory effect of IGF-I and the team led by Prof Jung Han Yoon Park found that luteolin affected cell signaling pathways which are activated by IGF-I in cancer. Prof Jung Han Yoon Park explained, "Luteolin reduced IGF-I-dependent activation of the cell signaling pathways PI3K, Akt, and ERK1/2 and CDC25c. Blocking these pathways stops cancer cells from dividing and leads to cell death."
Prof Jung Park continued, "Our study, showing that luteolin interferes with cell signaling in colon cancer cells, is a step forward in understanding how this flavonoid works. A fuller understanding of the in vivo results is essential to determine how it might be developed into an effective chemopreventive agent."
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The above story is reprinted from materials provided by BioMed Central Limited, via AlphaGalileo.
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Journal Reference:
- Do Young Lim, Han Jin Cho, Jongdai Kim, Chu Won Nho, Ki Won Lee and Jung Han Yoon Park. Luteolin decreases IGF-II production and downregulates insulin-like growth factor-I receptor signaling in HT-29 human colon cancer cells. BMC Gastroenterology, 2012 [link]
Note: If no author is given, the source is cited instead.
Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.
Source: http://www.sciencedaily.com/releases/2012/01/120122201213.htm
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Monday, January 23, 2012
Three-Year-Old Missouri Boy Battles Cancer | fox4kc.com ? Kansas ...
ST. LOUIS, Mo. ? A three-year-old Missouri boy is using his painting skills in an effort to save his life. His family plans to sell some of the toddler?s paintings to help pay for his cancer treatment.
Liam Myrick is like most three-year-olds. He likes cars, trucks and painting pictures.
?I want to eat at my house,? Myrick said.
For now, he spends his days and nights at Children?s Hospital in St. Louis. Last July, His mom Shawna took him to the doctor after he became sick.
?They ordered a CT and our lives changed,? said Shawna Myrick.
He was diagnosed with stage four Neuroblastoma. Doctors had found a tumor on top of his kidney. The toddler underwent excruciating chemotherapy. Just recently, he had a bone marrow stem cell transplant on the January 10, which is why the brave little boy has to remain in the hospital.
To help defray the costs of his medical expenses, the Myricks are auctioning Liam?s work on Facebook. To learn more click here.
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Source: http://fox4kc.com/2012/01/22/three-year-old-missouri-boy-battles-cancer/
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Honey Boo Boo Child on Dr. Drew?s Lifechangers
Dr. Drew Takes A Sip of Honey Boo Boo Child’s Go-Go-Juice on “Dr. Drew’s Lifechangers” airing February 2nd at 3:00pm on The CW
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Sunday, January 22, 2012
Asthma Meds Likely Safe During Pregnancy: Study (HealthDay)
FRIDAY, Jan. 20 (HealthDay News) -- A new study found no statistically significant link between asthma medication use during pregnancy and common birth defects.
However, the study did find a positive association between some rare birth defects and mothers with asthma, and potentially with their medication use. But, the researchers couldn't tease out whether the problem was a loss of oxygen from less than well-controlled asthma or an effect of medications.
"Worsening asthma is a risk to the mom and the fetus. Hypoxia (a lack of oxygen) we know is a problem for a developing fetus. And, the potential risk they found here is very small. Even if it turns out to be a true increase, the risk is so small. This study raises more questions than it answers," said Dr. Natalie Meirowitz, chief of the division of maternal fetal medicine at Long Island Jewish Medical Center in New Hyde Park, N.Y.
What's most important, she said, is that expectant mothers with asthma don't just stop their medications. "That's really a problem, and then they end up needing more medication," she said.
Findings from the study were published online Jan. 16, ahead of February print publication in Pediatrics.
Between 4 percent and 12 percent of expectant mothers have asthma, according to background information in the article. Current guidelines recommend that women keep taking their asthma medications during pregnancy.
There are two main types of asthma medications: bronchodilators (also known as rescue medication) and anti-inflammatories, which include inhaled and oral steroids, as well as several other medications. Anti-inflammatory medications are generally used long term to help control asthma symptoms.
For the study, the researchers compared nearly 2,900 infants born with birth defects to more than 6,700 babies born with no birth defects. Mothers of these infants were asked to recall their medication use one month before and during pregnancy.
For most birth defects, the researchers found no statistically significant associations between asthma medication use and the development of birth defects.
They did, however, find a positive association between asthma medication use and certain rare birth defects. The risk of isolated esophageal atresia -- an abnormality of the esophagus -- was more than doubled in women who used bronchodilators. The risk of isolated anorectal atresia -- a malformed anus -- was more than doubled with maternal anti-inflammatory use. And, the risk of omphalocele -- a defect in the abdominal wall -- was more than quadrupled for either type of asthma medication.
But, the authors wrote, the "observed associations may be chance findings or may be the result of maternal asthma severity and related hypoxia rather than the medication use."
They added that it's also important to keep these findings in context. The rate of these birth defects ranged from 1.2 to 4.6 per 10,000 births. So, even a four-fold increase in the risk of having one of these defects results in far less than a 1 percent chance for any individual woman and her child.
"As obstetricians, we need to pay attention to this, but it's really important to oxygenate mom. We really need to make sure that there's oxygen flowing freely between mom and baby," said Dr. Mary Rosser, an obstetrician with Montefiore Medical Center in New York City.
Also, Rosser pointed out that there was a lot that wasn't known about the expectant mothers. The authors weren't able to assess the severity of their asthma. They also didn't know anything about the medication doses.
Asthma expert Dr. Jennifer Appleyard agreed with Rosser and Meirowitz. "They really couldn't tease apart what was the medicine and what was the asthma," she said.
"You need to treat the asthma. There's more risk to uncontrolled asthma than a slight possible risk of a rare birth defect," said Appleyard, the chief of allergy and immunology at St. John Hospital and Medical Center in Detroit.
"No matter what type of patient you're treating -- expectant mom or not -- the goal is to treat patients with the minimum amount of medication necessary," she added.
Rosser and Meirowitz said that, ideally, women should visit their obstetrician/gynecologist before getting pregnant to review their medication use and to make sure that their asthma is well controlled.
More information
Learn more about asthma during pregnancy from the American College of Allergy, Asthma and Immunology.
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